NPS40TM

- Water-dispersible Phytosterol powder

- 40% of Phytosterol + FDA approved inactive ingredients

- Easily dispersible in water with high concentration

- Widely applicable to various types of water-based functional food products

Features: White Powder, Water-soluble (Stably dispersible in nanoparticles)

Spec: 40% of Phytosterol and 60% of FDA approved inactive ingredients

50mg/ml, 5mg/ml, 1mg/ml, 0.5mg/ml

The Challenge of Poor Solubility

- The water solubility of active pharmaceutical or nutraceutical ingredients is a key property governing dissolution, absorption, and in-vivo efficacy.

- Poor water solubility makes it difficult to incorporate active ingredients into water-based pharmaceutical, nutraceutical, or cosmetic products

-There are many approaches to address the challenge

? Particle size reduction

? Modification of polymorphs

? Drug suspension in carriers (e.g. solid dispersion)

? Use of complexing agents

? Solubilization by surfactants (e.g. microemulsion, SMEDDS)

The approach of Bio-Synectics

- The solution of Bio-Synectics for the poor solubility problem is to decrease the particle sizes of active ingredients to nanometer range

- The platform technologies of Bio-Synectics generate nano-sized particles efficiently for many poorly soluble ingredients

- The technologies of Bio-Synectics have the following advantages

? There is no burden of additional safety issues, as we are not using any special carriers to make nanoparticles and only use safe materials generally used in the industries

? They provide powder form outputs, which can be directly used for subsequent processes without typically needed drying steps of other nanoparticle technologies.

The Advantage of Nanoparticulation

- Enhanced bioavailability of orally administrated poorly soluble active ingredients

? Increased dissolution velocity allows enhanced bioavailability

? Decreased fed/fasted and inter-individual variations

- Improved formulation flexibilities

? By making colloidal particle dispersions, stable aqueous formulations can be developed

? The water-dispersion of nanosized particles provides convenient formulation solutions to incorporate poorly soluble ingredients into various types of functional food products or cosmetic products.